Endotyping asthma related to 3 different work exposures

BackgroundWork exposures play a significant role in adult-onset asthma, but the mechanisms of work-related asthma are not fully elucidated.ObjectiveWe aimed to reveal molecular associated with exposure flour (flour asthma), isocyanate (isocyanate or welding fumes (welding asthma) and identify potential biomarkers that distinguish these groups from each other.MethodsWe used combination clinical tests, transcriptomic analysis, pathway analyses investigate underlying disease blood immune cells airway epithelium 61 men.ResultsCompared healthy controls, patients had more differentially expressed genes than patients, both epithelia cells. In epithelia, active inflammation was detected only patients. contrast, many were all 3 groups. Disease-related functions cells, including leukocyte migration inflammatory responses, decreased expression upstream cytokines such as TNF IFN-γ suppressed transcriptome-phenotype correlations, hyperresponsiveness (R ∼ |0.6|) highest relevance set group–specific genes. Finally, biomarker subsets 5 specifically distinguished groups.ConclusionsThis study provides novel data on asthma. We identified promising related flour, isocyanate, fume be tested clinically validated future studies. Work elucidated. other. men. Compared This